Letrozole Facilitates Pregnancy in Women Suffering from Polycystic Ovary Syndrome (PCOS)
By Indrani Bhattacharyya | July 17, 2014 12:28 PM EST
Presently 5 to 10 per cent of reproductive-age women suffer from infertility because of PCOS.
Women suffering from PCOS usually have excessive levels of a hormone called androgen, infrequent periods, with development of small cysts on the ovaries and have trouble conceiving.
Clomiphene citrate known to stimulate ovulation has been used as the standard treatment for PCOS. But researchers say it has certain drawbacks and the success rate is no more than 22 per cent. It also causes some annoying side effects like hot flashes and frequent mood swings.
Letrozole is another drug which blocks estrogen production. It also increases the rate of pregnancy in women with PCOS , these results have appeared in the current issue of the New England Journal of Medicine by Dr. Richard Legro, professor of obstetrics and gynecology and lead author of the study.
In order to compare the effectiveness of these two drugs, scientists studied 750 infertile women with PCOS between 18 and 40 years old who wanted to get pregnant.
Women were randomly given clomiphene or letrozole and took the medications for up to five cycles, with increasing dosage at each cycle.
The group of women who took letrozole had a higher rate of live births ( 27.5 per cent) than the women who received clomiphene (19.1 per cent). Also ovulation rates were significantly higher with letrozole each month.
Fewer twin pregnancies occurred in the women who took letrozole (3.9 per cent) and 6.9 per cent on clomiphene. Clomiphene taking women experienced significantly higher incidence of hot flashes while letrozole caused significantly higher incidence of fatigue and dizziness. Birth defects were rare and rates were similar between the two medications, comparable to those from studies of women who conceive without treatment.
Further investigation is required with a larger number of infants to clarify the safety of letrozole.
To contact the editor, e-mail:
Most Popular Slideshows
- Still The World Champions: Team USA Overpowers Serbia, 129-92 To Win 2014 FIBA World Cup [PHOTOS]
- Kendall Jenner Could Be Next Victoria's Secret Angel [PHOTOS]
- From Fat To Fit: Celebrities Who Were Overweight Before They Became The Beauties That They Are
- Taylor Swift Named People's Best Dressed Stars Of 2014 [PHOTOS]
Join the Conversation
- Peter Quillin Claims That Adriana Lima Will Beat Gisele In The Boxing Ring; Adriana's Weight Loss Through Boxing and A Paleo Diet
- Joan Rivers May Have Died From Propofol Like Michael Jackson
- Kate Middleton Pregnancy: Middleton's Morning Sickness Could Cause Risk Of Miscarriage[Watch Video]
- Caution to Diabetics: Artificial Sweeteners May Increase Blood Sugar Levels Based on Study
- Prince Harry Turns 30 And Inherits $16 Million: Cancels Birthday Bash Due To Morning Sickness Of His Sister-in-Law Kate Middleton
- iOS 8 Release Date Of Sept 17 Has Arrived: Update Begins At 10AM Pacific Time, Upgrade Your iDevices With iOS 7.1.2 First To Install iOS 8
- Why Samsung Galaxy S5 Is Not The Best Smartphone To Purchase Now? If You Still Want To, Wait For A Month To Get It Cheap
- Apple iPad Air 2, iPad Mini 3 October Release Date Roundup: Freshly Leaked Protective Case Debuts Unique Vent Alongside Camera
- Google Nexus 6 Release Date on Q4 2014 Confirmed by T-Mobile Featuring Wi-Fi Calling
- Canadian IS Jihadist Wants to ‘Play Soccer’ with Heads of US Decapitated Soldiers
- Warning to U.S. – ISIS Has Shot Down a Syrian Regime Fighter Jet
- Spice Dream Uno vs Xiaomi Redmi 1S: Android One Smartphone to Challenge The Existing Budget Friendly Smartphone