'Grey's Anatomy' Season 10, Ep 22 Spoilers: Shonda Rhimes, Cristina Yang, Preston Burke; Viewers Reunite Too For Sandra Oh's Farewell [Watch Promo Video]

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By Arlene Paredes | May 2, 2014 4:50 AM EST

"Grey's Anatomy" Season 10, Episode 22, titled "We Are Never Ever Getting Back Together," airs May 1, Thursday on ABC. This begins the final three episodes of the season. Fans say farewell to Sandra Oh and Cristina Yang. Shonda Rhimes dishes thoughts on the return of Isaiah Washington's Preston Burke.

REUTERS/Eric Gaillard
Actor Jesse Williams who stars as Jackson Avery in the television series 'Grey's Anatomy' at the 51st Monte Carlo television festival in Monaco.

Spoiler alert: This feature contains spoilers and speculations on Grey's Anatomy Season 10, Episode 22. The season finale airs May 15 on ABC. Read at your own risk.

Viewers who have stopped watching Grey's Anatomy (and not seen Season 10) are likely to revisit the medical drama. Isaiah Washington returns as Preston Burke for the first time in seven years. This is still part of Shonda Rhimes' "Farewell to Cristina Yang" story.

Speaking to Entertainment Weekly, Rhimes recognizes the power of the Yang-Burke partnership. It is damaging to both characters, she notes. But it is their very "struggle" that kept many viewers glued to Grey's Anatomy until Burke left Yang at the altar in the Season 3 finale.

Grey's Anatomy Season 10, Episode 22 is a grand reunion in two ways. Burke and Yang reunite in the TV screen, and viewers reunite with the two powerhouse characters. The title, however, does not want to encourage romantic hope. But "We are never ever getting back together" can be a misdirection, too.

Cristina Yang walks out of Grey Sloan Memorial. She is probably considering a new work environment. The Grey's 10x22 press release says Cristina asks Meredith (Ellen Pompeo) for advice. This could be about leaving the hospital (or leaving Kevin McKidd's Owen Hunt for good).

"(P)eople really loved them together - as damaging as that relationship was for both of them. I think people really loved watching them struggle," Rhimes told Entertainment Weekly. The ratings for Grey's 10x22 might prove the Shondaland queen is right.

Yang lectures. Burke asks. They talk, and Burke convinces Cristina to agree on something. This happens in Grey's Anatomy Season 10, Episode 22. On the intern side, Jo Wilson (Camilla Luddington) may have bitten more than she could chew in terms of work load. And Stephanie (Jerrika Hinton) may have unlocked the mystery in Bailey's patient's case. Meanwhile, Jackson Avery (Jesse Williams) and April Kepner (Sarah Drew) are pregnant.

In the Grey's Anatomy Season 10 finale synopsis, a send-off for Yang is mentioned among other things. There is a "possible terrorist act" and an "alarming news" that might be isolated from the former. "Meredith makes a life-altering choice." Shonda Rhimes will be making the Grey's fans cry - again.

WATCH: Grey's Anatomy Season 10, Episode 22 Spoilers (ABC Promo Video HD on YouTube)

Shonda Rhimes Teases Grey's Fans on Twitter: 'Burke is Back'

Grey's Anatomy Season 10, Episode 22 airs on ABC on May 1. The next new episode, "Everything I Try to Do, Nothing Seems to Turn Out Right," airs on May 8.

More TV Guide and Spoiler Features

'Grey's Anatomy' Season 10, Episode 21 Spoilers: 'Mer' Bids Cristina Yang Goodbye; Preston Burke Returns in 10x22 [Watch Promo Videos]
'Grey's Anatomy' Season 10 Spoilers: Shonda Rhimes Prepares Fans for the Big Cristina Yang Goodbye [Watch 10x19 Promo Video] 

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(Photo: REUTERS/Eric Gaillard / )
Actor Jesse Williams who stars as Jackson Avery in the television series 'Grey's Anatomy' at the 51st Monte Carlo television festival in Monaco.
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