Where to Watch Live
The game is scheduled for an 8.45 pm CET (1.15 am IST Wednesday morning, 2.45 pm ET) start with live coverage on Ten HD and Ten Action in India. The match can also be watched via live streaming online in India HERE. Catch the action in the US HERE, while Australia and New Zealand viewers can live stream the game HERE. Viewers in the UK can watch the action via live streaming HERE, while Latin America viewers can go HERE. The match can be live streamed in the Middle East and North Africa HERE, while the rest of Africa viewers can catch the action HERE. Viewers in Germany can live stream the game HERE, while Canada viewers can catch the action HERE. Live stream the game in Italy HERE.
United did rather well in the group stages, topping their group to ensure they would not have too tricky a draw in the first phase of the knockout stages.
Having picked up a 2-0 victory over Crystal Palace at the weekend, following a spell of warm-weather training in Dubai, David Moyes and co. will be determined to continue the winning run come Tuesday.
"It's a really tough game, Olympiakos have a good record here and we know, over the tie, we'll have to play well to qualify," Moyes said.
"Olympiacos did very well against PSG and Benfica. They came through a difficult group, they have a great home record here. We know it will be a difficult night. They have a big support. It's far from an easy match."
With 11 points currently separating them from fourth-placed Liverpool and the last Champions League place, United will be aware their best chance, at the moment, of qualifying for Europe's elite tournament next season is by going all the way and claiming the title this campaign.
"The main aim is to get the right result on Tuesday and then take each game as it comes," Wayne Rooney said. "The year Chelsea won it they nearly went out about three times.
"You just have to keep going, whether or not we get the right result or not. We're looking to get the victory and then progress to the quarterfinals."
Olympiakos, unbeaten in 26 league matches but making their first knockout stage appearance in four years, have little to lose going into the last 16 fixture, knowing that United, even this side bereft of confidence, are the overwhelming favourites.
The first leg at home will be crucial for the Greek side - if they can prevent United from scoring, and take a lead, any lead, into the second leg, then an upset might just be possible.
"I'm delighted to have reached this stage and can't wait for tomorrow's match," Michel said on Monday. "The stakes are high and we won't give anything away. Of course experience counts but we have the ability to overcome our lack of it.
"The passion we have displayed to get here will serve us well against United and cause them problems. We will do everything in our power to beat them tomorrow night.
"We are in better shape than we were two months ago. We have been working hard and everyone is well prepared. The players are extremely motivated and raring to go.
"United are a top-class team and I will not comment on their form. They cannot afford to make any errors given their position in the Premier League. We also can't afford to give anything less than 100 percent."
Team news: Olympiakos: Javier Saviola has been ruled out for the Greeks, while Giannis Maniatis, Ivan Marcano, Delvin N'Dinga, Alejandro Dominguez and Michael Olaitan were rested in the 4-0 victory over Crete at the weekend.
Manchester United: Juan Mata is cup-tied and cannot represent his new club in this season's Champions League. Phil Jones and Jonny Evans also miss out, with the England duo not travelling to Greece due to injuries.
Key men: Olympiakos: On-loan Arsenal forward Joel Campbell will look forward to making his mark against the English Premier League champions.
Manchester United: With Mata out, the onus, as it always is, will be on Rooney and Robin Van Persie to find an away goal or two.
Expected lineups: Olympiakos: Roberto; Salino, Medjani, Manolas, Bong; Samaris, Maniatis; Campbell, Dominguez, Fuster; Olaitan.
Manchester United: De Gea; Smalling, Ferdinand, Vidic, Evra; Carrick, Fletcher; Valencia, Rooney, Januzaj; Van Persie.
Prediction: 2-1 to Manchester United
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