Fatty Food Intake During Puberty May Lead to Breast Cancer
By Roshni Mahesh | November 27, 2013 9:15 PM EST
Excess intake of saturated fats during teenage years can increase the risk of breast cancer in women, according to study by Michigan State University.
Researchers found that girls who followed a high-fat diet during puberty were at greater risk of developing the disease.
While conducting experiments on mice, Sandra Haslam and her colleagues noticed that a diet high in saturated animal fat altered normal structure of the breast by promoting excess cell growth and making alterations in immune cells. The process ended up with the development of certain precancerous lesions (tissues that are more prone to cancer), and finally breast cancer.
Saturated fat intake was particularly associated with the development of an aggressive type of breast cancer that is basal-like in young women. These types of cancers are included in the triple-negative breast cancer types. Breast cancer cells testing negative for oestrogen receptors (ER), progesterone receptors (PR) and HER2 are termed as triple-negative breast cancer. It is not caused by the hormones oestrogen or progesterone. So tamoxifen (hormonal therapy) or Herceptin (therapy that target HER2 receptors) are less effective in treating this type of cancer.
"This is very significant because even though the cancers arise from random mutations, the gene signature indicating a basal-like breast cancer shows the overarching and potent influence this type of diet has in the breast," lead investigator of the study, Haslam, said in a statement.
A high-fat diet that doesn't lead to weight gain was also equally associated with an increased risk of cancer. "It's important to note that since our experimental model did not involve any weight gain from the high-fat diet, these findings are relevant to a much broader segment of the population than just those who are overweight," researcher Richard Schwartz expalined. "This shows the culprit is the fat itself rather than weight gain."
Diet always has an important role in both prevention and treatment of breast cancer. Research conducted at Thomas Jefferson University Hospital in the US recently showed that restricting caloric intake during breast cancer treatment helped improve the outcome.
To contact the editor, e-mail:
Most Popular Slideshows
- Prince William & Kate Middleton Caught Flirting In A Countryside Dinner Date [PHOTOS]
- Kate Middleton’s Mom Accused Of Being A Social Climber, Prince George Not Seen By Relatives
- 2014 US Open: Hottest Female Tennis Athletes [PHOTOS]
- Prince William & Kate Middleton Boards London Train in Casual Disguise, Royal Couple’s Incognito Plan A Huge Hit [PHOTOS]
Join the Conversation
- Ebola: American Doctors in Liberia Trying Out New Methods
- Low-Carb Diet Helps Reduce Risk of Heart Disease, Aids Weight Loss; A Look At Celebs Who Adopted The Diet
- 5 Deadly Reasons to Stay Away From Soda (Watch Video)
- Boxing News 2014: 12 Days to Mayweather-Maidana Rematch; Money May’s Bikram Yoga Routine Includes Placing $100 Bills Around Mat
- More Than Two Hundred Colombian Girls Hospitalized After Receiving Cervical Cancer Vaccination
- 5.5-Inch iPhone 6 is iPhone Air on Sept 19 Release Date: 5 Things to Consider Before Buying
- Pricey iPhone 6 on Release Date Likely but with 3X Retina Resolution & Mobile Payment Service – Reports
- Nexus 6 Release Date Update: Moto X+1 Look Leaked, Nexus X or Shamu Moved to Demo Phase
- Google Nexus 8 Confirmed as HTC T1 aka Volantis/Flounder with Freshly-Leaked Specs & Features – Reports
- HTC One M8 for Windows Vs. Nokia Lumia Icon, The Battle Of Windows Phones
- Europe, US Next on ISIS’ Hit List, Says Saudi King; Seized ISIS Laptop Reveals Terrifying Bio-Warfare Plans
- iPhone 6 On Release Date To Feature Qualcomm MDM9625M LTE, 1GB RAM, Mobile Payment Deal With AMEX, 1334x750 Display