Fatty Food Intake During Puberty May Lead to Breast Cancer
By Roshni Mahesh | November 27, 2013 9:15 PM EST
Excess intake of saturated fats during teenage years can increase the risk of breast cancer in women, according to study by Michigan State University.
Researchers found that girls who followed a high-fat diet during puberty were at greater risk of developing the disease.
While conducting experiments on mice, Sandra Haslam and her colleagues noticed that a diet high in saturated animal fat altered normal structure of the breast by promoting excess cell growth and making alterations in immune cells. The process ended up with the development of certain precancerous lesions (tissues that are more prone to cancer), and finally breast cancer.
Saturated fat intake was particularly associated with the development of an aggressive type of breast cancer that is basal-like in young women. These types of cancers are included in the triple-negative breast cancer types. Breast cancer cells testing negative for oestrogen receptors (ER), progesterone receptors (PR) and HER2 are termed as triple-negative breast cancer. It is not caused by the hormones oestrogen or progesterone. So tamoxifen (hormonal therapy) or Herceptin (therapy that target HER2 receptors) are less effective in treating this type of cancer.
"This is very significant because even though the cancers arise from random mutations, the gene signature indicating a basal-like breast cancer shows the overarching and potent influence this type of diet has in the breast," lead investigator of the study, Haslam, said in a statement.
A high-fat diet that doesn't lead to weight gain was also equally associated with an increased risk of cancer. "It's important to note that since our experimental model did not involve any weight gain from the high-fat diet, these findings are relevant to a much broader segment of the population than just those who are overweight," researcher Richard Schwartz expalined. "This shows the culprit is the fat itself rather than weight gain."
Diet always has an important role in both prevention and treatment of breast cancer. Research conducted at Thomas Jefferson University Hospital in the US recently showed that restricting caloric intake during breast cancer treatment helped improve the outcome.
To contact the editor, e-mail:
Most Popular Slideshows
- From Fat To Fit: Celebrities Who Were Overweight Before They Became The Beauties That They Are
- Kendall Jenner Could Be Next Victoria's Secret Angel [PHOTOS]
- Champions League Results: Barcelona Barely Escapes With A Win, Chelsea Fails To Hold On To The Lead [PHOTOS]
- Taylor Swift Named People's Best Dressed Stars Of 2014 [PHOTOS]
Join the Conversation
- 'Keeping Up With The Kardashians' Star Kourtney Kardashian Blamed For Khloe's Weight Gain Through Social Media Messages
- Peter Quillin Claims That Adriana Lima Will Beat Gisele In The Boxing Ring; Adriana's Weight Loss Through Boxing and A Paleo Diet
- Caution to Diabetics: Artificial Sweeteners May Increase Blood Sugar Levels Based on Study
- Kate Middleton Pregnancy: Middleton's Morning Sickness Could Cause Risk Of Miscarriage[Watch Video]
- Ebola Update: Australian Aid Worker Appeals For More Field Hospitals, U.S. Steps Up Efforts To Fight Virus
- iOS 8 Release Date Of Sept 17 Has Arrived: Update Begins At 10AM Pacific Time, Upgrade Your iDevices With iOS 7.1.2 First To Install iOS 8
- Google Nexus 6 Release Date on Q4 2014 Confirmed by T-Mobile Featuring Wi-Fi Calling
- Why Samsung Galaxy S5 Is Not The Best Smartphone To Purchase Now? If You Still Want To, Wait For A Month To Get It Cheap
- Apple iPad Air 2, iPad Mini 3 October Release Date Roundup: Freshly Leaked Protective Case Debuts Unique Vent Alongside Camera
- Canadian IS Jihadist Wants to ‘Play Soccer’ with Heads of US Decapitated Soldiers
- Australia Actively Rallying Support For International Coalition Against ISIS
- Warning to U.S. – ISIS Has Shot Down a Syrian Regime Fighter Jet