The stunning beauty was dressed in her trademark black gown and was accompanied by partner Brand Pitt and son Maddox.
The Oscar-winning actress could not hide her tears when she delivered her emotional speech to her late mother, Marcheline Bertrand and dedicated her award to her mom. The star-studded award ceremony took place on Saturday. The jury mentioned about Angelina's more than 40 field missions that included helping refugees from Cambodia and Syria.
"My love, your guidance and support make everything that I do possible," said a tearful Jolie as she thanked Brad Pitt.
"Mad, I'm not going to cry, I promise. I won't embarrass you. You and your brothers and sisters are my happiness. And there is no greater honour in this world than being your mom," the "Tomb Raider" actress said thanking her 12-year-old son Maddox.
The 38-year-old star then went on to thank the woman she admired the most - her mother.
"I am very humble to be here tonight among so many extraordinary artists. My mother loves art. She loved film. She supported any crazy thing I did, but whenever it had meaning, she made a point of telling me,' 'That is what film is for'," Angelina said.
The actress then revealed how her charitable work around the globe made her realise how life is really about surviving all hardships. When she saw what drastic lives people across the world are leading she thanked God for her good life and family.
"And when I met survivors of war and famine and rape, I learned what life was like for most people in this world. And how fortunate I was to have food to eat, a roof over my head, a safe place to live and the joy of having my family safe and healthy. And I realized how sheltered I had been. And I was determined to never be that way again," the mother of six said.
Tom Hanks, Jake Gyllenhaal, Diane Keaton, Judd Apatow, Harrison Ford, Amy Adams, Matthew McConaughey, and George Lucas were among the few who attended the gala event. See the video of Angelina Jolie's acceptance speech below. Angelina Jolie Gets Emotional