Follow minute by minute coverage of all tonight's action on IB Times UK's LIVE blog here.
Where to Watch Live
Kick-off is set for 7:45pm BST. Live coverage will be available on Sky Sports 4 and Sky Sports 4 HD.
Shakhtar have made a lacklustre start to their league campaign, having won only one of their last five games. The Ukrainian giants have won the league the last four years but currently find themselves in third position, dropping 10 points in the run-in. However, their record against English opposition at home is commendable, winning their last three fixtures, two against Arsenal and one against Chelsea last year.
Manager Mircea Lucescu will be hoping that a good performance against one of the greats in Europe will put their season back on track. Their last game in the league ended in a 2-2 draw against Metalurh Donetsk, with former Arsenal star Eduardo coming on from the bench to score the equaliser. Shakhtar are currently level on points with United in the group, having won their first group game 2-0 against Spanish side Real Sociedad.
Manchester United have started the season in dismal fashion, having secured only seven points from their last six games in the league. The reigning Premier League Champions are currently 12th in the league, eight points behind league leaders Arsenal. The Red Devils come into the game on the back of a disappointing 2-1 loss to West Bromwich Albion and know that a loss here will add to the mood of crisis among the fans.
David Moyes, who took over from Sir Alex Ferguson is yet to find the right balance in the squad and has already suffered three defeats in the league including a 4-1 humiliation at the hands of Manchester City. However, the Scotsman will take inspiration from his side's 4-2 win over Bayer Leverkusen in the first round of the Champions League, and will be hoping for a similar performance from against an out-of-form Ukrainian side.
What the Managers Say
Mircea Lucescu: "In the Ukrainian championship we are not rotating the squad as much about United so maybe that is why we have been more secure. Our players must be very determined and show their quality because we're expecting a cauldron in our stadium."
David Moyes: "The results will come, there's no doubt about that. I've been in situations very similar to this at my old clubs Everton and Preston North End. I haven't changed what I've done - you continue to do the right things. It's always the thing at United. Everybody is interested in them. It's a talking point throughout the world."
Last Five (all competitions, most recent first): D W W W L
Last Result: Metalurh Donetsk 2-2 Shakhtar Donetsk
Last Five (all competitions, most recent first): L W L W W
Last Result: Manchester United 1 - 2 West Bromwich Albion
Probable Line-up: Pyatov; Srna, Kucher, Shevchuk, Rakitskiy; Hubschman, Teixeira, Costa, Bernard, Luiz Adriano; Taison
Injured: Rio Ferdinand (groin), Tom Cleverly (knee)
Probable Line-up: De Gea; Evra, Vidic, Evans, Rafael; Valencia, Carrick, Fellaini, Nani; Rooney, Van Persie
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