Groundbreaking Ovarian Technique Helps Women with Early Menopause Become Mothers
By Roshni Mahesh | October 1, 2013 6:22 PM EST
A new technique can help women experiencing early menopause to conceive successfully. The first baby conceived via this technique was delivered successfully and the second baby is on the way.
Premature ovarian insufficiency or premature ovarian failure is a condition where women experience menopause early, around age 40. It is a condition caused by the scarcity of sufficient eggs and follicles in the ovary, and is different from premature menopause. Women with premature ovarian failure can become pregnant unlike those who had premature menopause. .
The trial involved 27 Japanese women, who were diagnosed with primary ovarian insufficiency and aged around 30. Thirteen of them had residual or leftover follicles in their ovaries.
During the procedure, known as in vitro activation (IVA), scientists from the St Marianna University medical school in Japan and Stanford University in the US removed a portion of the ovary from the participants.
The ovaries were subjected to treatment outside, including mechanical fragmentation and application of drugs, to block the activity of protein PTEN. The ovary pieces were then placed back into the fallopian tubes. Among them, eight women showed follicle growth. The participants later underwent hormone therapy and later in-vitro fertilisation (IVF) treatment.
"Although there are too little data available about this experimental treatment to guarantee any kind of success rate, the approach does look quite promising for women who have run out of eggs," said Valerie Baker, MD, associate professor of obstetrics and gynecology and chief of Stanford's division of reproductive endocrinology and infertility.
Scientists said the new technique can treat infertility in women caused by cancer chemotherapy or radiation. "We think it could help in two other forms of infertility. Cancer survivors after chemotherapy or radiotherapy; if there's any follicles left there's a chance this will help," senior author of the study, Dr. Aaron Hsueh, professor of obstetrics and gynecology at Stanford, told the BBC. "And also women aged 40 to 45 with an irregular menstrual cycle."
Findings of the study have been published in the online edition of the Proceedings of the National Academy of Sciences.
To contact the editor, e-mail:
Most Popular Slideshows
Join the Conversation
- HIV Cure: Modified Gene Therapy Causing Resistance And Mysterious Enzyme Could Unlock Effective Treatment
- Using Hand Dryers in Public Restrooms Could Spread Germs
- Text Neck Causes More Harm Than You Think
- Kourtney Kardashian Thinks Pregnancy Nausea Should Not Be Called 'Morning Sickness' Because It Lasts All Day
- Beating Postnatal Depression Is Just A Phone Call Away
- Russia's New Tactical Nuclear Weapons Program Growing Confident Against the US: Talks of World War III
- Apple and Google Engage in Thermonuclear War, New Google Translate Chat App in the Works
- Kobani ISIS Fighter Sends Out Desperate Message For Prayers And Support: Euphoria Turns Into Desperation As Kurds Advance
- Chris Algieri’s Battered Face Trends On Social Media
- Home Depot Early Black Friday 2014 Sale Up To Nov. 29, 2014 Includes Special Buys On Appliances Such As Samsung Refrigerators, Whirlpool Electric Ranges And Hoover Vacuum Cleaners
- Highest Paid NBA Players 2014: NBA Stars Who Earn More Than LeBron James
- Walmart Offers the Best 2014 Black Friday Deals on iPhone 6, iPad Ai2 & Other Gadgets – Reports