Groundbreaking Ovarian Technique Helps Women with Early Menopause Become Mothers
By Roshni Mahesh | October 1, 2013 6:22 PM EST
A new technique can help women experiencing early menopause to conceive successfully. The first baby conceived via this technique was delivered successfully and the second baby is on the way.
Premature ovarian insufficiency or premature ovarian failure is a condition where women experience menopause early, around age 40. It is a condition caused by the scarcity of sufficient eggs and follicles in the ovary, and is different from premature menopause. Women with premature ovarian failure can become pregnant unlike those who had premature menopause. .
The trial involved 27 Japanese women, who were diagnosed with primary ovarian insufficiency and aged around 30. Thirteen of them had residual or leftover follicles in their ovaries.
During the procedure, known as in vitro activation (IVA), scientists from the St Marianna University medical school in Japan and Stanford University in the US removed a portion of the ovary from the participants.
The ovaries were subjected to treatment outside, including mechanical fragmentation and application of drugs, to block the activity of protein PTEN. The ovary pieces were then placed back into the fallopian tubes. Among them, eight women showed follicle growth. The participants later underwent hormone therapy and later in-vitro fertilisation (IVF) treatment.
"Although there are too little data available about this experimental treatment to guarantee any kind of success rate, the approach does look quite promising for women who have run out of eggs," said Valerie Baker, MD, associate professor of obstetrics and gynecology and chief of Stanford's division of reproductive endocrinology and infertility.
Scientists said the new technique can treat infertility in women caused by cancer chemotherapy or radiation. "We think it could help in two other forms of infertility. Cancer survivors after chemotherapy or radiotherapy; if there's any follicles left there's a chance this will help," senior author of the study, Dr. Aaron Hsueh, professor of obstetrics and gynecology at Stanford, told the BBC. "And also women aged 40 to 45 with an irregular menstrual cycle."
Findings of the study have been published in the online edition of the Proceedings of the National Academy of Sciences.
To contact the editor, e-mail:
Most Popular Slideshows
- NFL MNF: Washington Redskins 20, Dallas Cowboys 17 (OT) [PHOTOS]
- Emma Watson Gets 'Squished' In 'Colonia Dignidad' [PHOTOS]
- 2014 MLB World Series Game 6: Kansas City Royals 10, San Francisco Giants 0 [PHOTOS]
- San Francisco Giants Beat Kansas City Royals, 3-2 In Game 7, Wins 2014 MLB World Series [PHOTOS]
Join the Conversation
- New String Of Ebola In The Democratic Republic Of The Congo; DFAT Advises Against Travel
- Sex Change Surgery Gets Enhanced Cover From US Insurance Firms: Obama Regime's Policy Change Became The Trigger
- Sex With 20 Women Or More Reduces Risk Of Prostate Cancer, Canadian Research Says
- From 30-Inch To 16-Inch Waistline, Woman Shrinks Self With Corset [Video]
- Red Cross Aussie Nurse Says Australia’s Ebola Visa Ban Is Embarrassing
- Marvel Announces Release Dates Of 11 Upcoming Movies From 2015 To 2019
- Xiaomi Becomes World’s Third Largest Smartphone Manufacturer By Dethroning Huawei
- Entry Of Peshmerga Fighters From Iraq Boosts The Kobani Battle Against ISIS: Turkey Provides Transit
- Nokia Lumia 730 v. Sharp Aquos Crystal – Specifications, Features And Price Showdown
- Nexus 6, 9 Buyers on November Release Will Enjoy These 3 Killer Lollipop 5.0 Features First
- Australia Special Forces Await 'Delayed' Iraqi Visas Before Joining ISIS Fight
- Woman Hanged In Iran Talks Abuse In Prison, Left Chilling Message To Family