Considered giants in their respective countries, Borussia Dortmund clashes with Napoli on matchday 1 of the UEFA Champions League.
Higuain and Aubemayangn will be battling it out to score goals on Tuesday.
Dortmund is streaking-hot in the Bundesliga, leading the table with 15 points, while maintaining a 100 per cent winning record.
Goal scoring does not seem to be a problem for Die Schwarzgelben as summer signings Pierre-Emerick Aubemayan and Henrik Mkhitaryan racked up five and three, respectively.
Old reliable Robert Lewandowski and Marco Reus have three and two to their name.
Dortmund reached the apex of the Champions League during the 2012/13 season, only to fall prey to domestic rivals Bayern Munich
Despite the aforementioned setback and losing the phenomenal Mario Gotze over the summer, the German side, under the guidance of well-rounded manager Jurgen Klopp, has found new life and has been impressive, thus far.
They are fresh off a 6-2 crushing victory over Hamburger SV in the Bundesliga.
While everything is going their way, Lewandowski still keeps his head in the game.
"It's going to be difficult for us, as Napoli have a really good team. But I'm hoping that we can start the campaign off with a win. It would send out just the right signal for us. We don't have to be worried, though. They're a strong team, but so are we." Lewandowski told bundesliga.com.
Skipper Sebastian Kehl, Łukasz Piszczek, and İlkay Gündoğan's presence on Wednesday remains doubtful because of injuries.
Meanwhile, Napoli, under the helm of the recently appointed manager, Rafael Benitez, is equally impressive.
They were able to snatch prolific striker Gonzalo Higuain from Real Madrid in the summer transfer window as a replacement for Edinson Cavani and has not looked back since then.
Higuian, along with another signing from Real, Jose Callejon, who have tallied a total of 3 goals in the Serie A, will be leading the Partenopei on Wednesday.
They are also undefeated in three games in the Serie A, leading the league with 9 points.
There have been no reports of key players sustaining injuries, so far.
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