The BSE Sensex falls 0.26 percent, while the Nifty falls 0.4 percent, off highs on profit-taking after the Nifty futures breached the key psychological level of 6,000 for the first time since Jan 7, 2011.
Traders also cite renewed concerns about India's current account deficit after data on Tuesday showed exports fell 4 percent to $22.3 billion in November, while imports jumped to $41.5 billion, leaving a trade deficit of $19.3 billion.
Traders focused on the outcome of factory data on Wednesday and inflation data on Friday, which are coming ahead of RBI's rate-setting meet on December 18.
Rate sensitive stocks come under pressure: State Bank of India falls 1 percent, Tata Motors falls 1.4 percent.
Tata Consultancy services shares down 0.9 percent have fallen 6.04 percent in past 5 sessions on outlook concerns.