Cure for Malaria: Scientists Identify Disease's Achilles' heel and Bring Hope to Millions
By Hannah Osborne | October 26, 2012 2:53 AM EST
A potential treatment discovered by disease scientists could eradicate malaria, which kills up to three million people every year.
Researchers at Imperial College London, along with scientists at Institut Pasteur and CNRS in France, have identified a way to rapidly kill the blood-borne Plasmodium parasites that cause the disease.
The Plasmodium quickly develop resistance to current treatments available for malaria. The new potential treatment interferes with an important stage in the parasites' development and kills them.
The researchers found two chemical compounds that are able to kill the parasite during its life cycle, while it inhabits the blood-stream. The molecules were also able to kill off strains of Plasmodium that had become drug resistant.
It was found that the treatment kills 90 per cent of the parasites in just three hours. It killed all the parasites in the laboratory samples of infected human blood cells within 12 hours.
Malaria predominately affects vulnerable people, such as pregnant women and children under five, in tropical regions of Africa, Asia and Latin America.
Speaking about the possible eradication of the disease, lead researcher, Dr Matthew Fuchter, from Imperial College London, said: "Plasmodium falciparum causes 90 per cent of malaria deaths, and its ability to resist current therapies is spreading dramatically.
"Whilst many new drugs are in development, a significant proportion are minor alterations, working in the same way as current ones and therefore may only be effective in the short term. We believe we may have identified the parasite's 'Achilles' Heel', using a molecule that disrupts many vital processes for its survival and development.
"One particularly exciting aspect of this discovery is this new molecule's ability to rapidly kill off all traces of the parasite, acting at least as fast as the best currently available antimalarial drug."
Oxfam recently said that that the Affordable Medicines Facility for malaria (AMFm) scheme, currently being used to treat people with malaria, is not working and could be endangering lives.
Under the scheme, shopkeepers can sell malaria drugs. However, sellers are not trained to diagnose malaria, so may well be providing these drugs to people who do not have the disease.
Dr Mohga Kamal Yanni, Oxfam's senior health policy advisor, said: "It is dangerous to put the lives of sick children in the hands of a shopkeeper with no medical training and to pursue a scheme that doesn't help those people who need it the most.
"There is no cheap option or short cut to combat malaria. The AMFm is a dangerous distraction from genuine solutions like investing in community health workers, who have slashed the number of malarial deaths in countries such as Zambia and Ethiopia."
The researchers now plan to refine the molecules and improve their effectiveness. It is hoped they will be able to develop a cure for malaria within a decade.
To contact the editor, e-mail:
Most Popular Slideshows
- Top 5 Richest Tennis Athletes
- Angelina Jolie & Brad Pitt Heads to Malta For New Movie After A Whirlwind French Wedding [PHOTOS]
- 2014 US Open Update (Day 4 - Men's Singles): Murray, Djokovic, Raonic and Isner Advance to 3rd Round [PHOTOS]
- Kate Middleton’s Mom Accused Of Being A Social Climber, Prince George Not Seen By Relatives
Join the Conversation
- Centerplate CEO Des Hague Caught Abusing Dog In Vancouver Building Elevator [VIDEO]
- Boyfriend's Welcome Home Tribute In Candles Destroys His House
- The Most Insane Facts About The American Civil War That You May Not Know
- Viral Video Kevin Droniak Grandma: Teenager Shows Grandma Their Videos Together, Grandma Gives Priceless Reaction
- Major Highlights On 1400 Minor’s Sex Assault
- Apple iWatch is iPhone 6 Accessory on Sept 19 Release Date: 6 Confirmed Specs & Features
- iPhone 6 Release Date Update: 4.7-Inch Model Scores 65.8% In Screen-To-Size Ratio; A Surprise Entry Scales Top Spot [List Attached]
- Canada Vs Russia War Erupts Via Twitter on Russia-Not Russia Maps
- Product Recall Alert: Hewlett-Packard Pulls Out 6M Power Cords from US, Canada Over Fire Hazard Concerns, Australia Also Affected
- ISIS Wants $6.6M and Release of Aafia Siddiqui in Exchange of Head of Female US Humanitarian Aid Worker, 1st American Fighting for Jihadis Dead
- James Foley Torture Involves CIA Waterboarding Technique
- Ukraine Ceasefire Looks Remote As Putin Talks Tough At Meeting With Poroshenko