Actress Katie Holmes filed for divorce from her husband of five years, actor Tom Cruise, and this marks the third divorce for the "Mission Impossible" star.

"Kate has filed for divorce, and Tom is deeply saddened and is concentrating on his three children," Cruise's representative told People magazine. "Please allow them their privacy."

Holmes' lawyer also spoke: "This is a personal and private matter for Katie and her family. Katie's primary concern remains, as it always has been, her daughter's best interest."

This was Holmes' first marriage and, now, her first divorce. She was linked to only two men before she commenced a relationship with Cruise. One was her "Dawson's Creek" co-star Joshua Jackson; the other was "American Pie" actor Chris Klein, to whom she was engaged at one point.

However, Cruise had walked down the aisle, and up to divorce court, twice before. Let's take a walk down memory lane and look at Cruise's former flames.

Actor Tom Cruise

Tom Cruise and Katie Holmes began dating in 2005, shortly after she broke up with her fiance, actor Chris Klein. She gave birth to their daughter in April 2006 and wed Cruise in a lavish ceremony in Italy in November of the same year.

Tom Cruise married actress and sometime-co-star Nicole Kidman (“Moulin Rouge!,” “The Others”) in 1990. They adopted two children together. The couple divorced in 2001. Kidman is now married to New Zealand-born singer Keith Urban, with whom she has two biological daughters.

Mimi Rogers

Tom Cruise dated “Vanilla Sky” co-star Penelope Cruz from 2001 to 2004. She is now married to actor and fellow Spaniard Javier Bardem, with whom she has a son.

Tom Cruise was rumored to have dated his “Risky Business” co-star Rebecca De Mornay, but this was not so, according to a 1983 People magazine report (although this same report indicated the two were close friends).

Yup, Tom Cruise and Cher dated briefly in the 1980s, according to People magazine. Weird, we know. "He was so wonderful,” Cher told the Huffington Post of Cruise in 2008. “And I was so crazy about him. And he was so, like, different. He was a shy boy. He didn't have any money."