The 28-year-old billionaire's wedding took place a day after Facebook's initial public offering on the Nasdaq stock exchange on Friday.
More than 280,000 people 'liked' Mr Zuckerberg's status change, which was accompanied by a photo of the smiling couple in wedding attire in a small, verdant outdoor setting with a string of lights behind them.
In the photo, the famously casual billionaire is wearing a dark blue suit and tie, a departure from his trademark 'hoodie', while Ms Chan has on a sleeveless white dress with lace overlay.
"The wedding had been planned for months and the couple was waiting for Chan to finish medical school, but the date of the IPO was a 'moving target' not known when the wedding was set.", spokesperson of the couple said.
Meanwhile, Dr. Chan was never going to be a stereotypical billionaire's wife of the many-spouses-of-Donald-Trump variety. The 27-year-old bilingual Mandarin speaker graduated from Harvard in 2007, the year after Zuckerberg would have earned his degree if he hadn't left to focus on Facebook - or thefacebook, as it was then known.
The two dated on and off during their undergrad years, first meeting in 2004. After Harvard, Massachusetts native Chan spent two years teaching science at the prestigious Harker School in San Jose before beginning her medical studies at UCSF, one of the top programs in the country. She only moved into Zuckerberg's $7 million Palo Alto pad in 2010.
Contrary to the golddigger jokes pervading Twitter, Chan won't be retiring to start a jewelry line or other such vanity project now that she and Zuckerberg are official. She aims to begin her work as a pediatrician later this year. Chan joins a group of Silicon Valley billionaire spouses who are achievers in their own right rather than kept women or arm candy.
The couple adopted a Hungarian sheepdog named Beast a year ago, and live together in Palo Alto.