Spain's theme for their upcoming match is about bouncing back and proving that they are still the team to beat in Group B, while it is Chile's time to show that they can slug it out with the big boys.
It will be interesting to see whether La Roja boss Vicente del Bosque will still stick with Iker Casillas following a sloppy performance against the Netherlands, wherein he allowed the ball to get past him five times. Pepe Reina is the only available replacement as David de Gea is out with a hip injury.
The other question lies on the frontline: will he still play an out-and-out striker in Diego Costa or Fernando Torres, or will he revert back to using a false-9 in Cesc Fabregas.
"If we make changes we won't be pointing the finger at anyone," said the 63-year-old mentor.
Projected Starters (4-2-3-1): Casillas; Alba, Juanfran, Ramos, Pique; Alonso, Busquets; Iniesta, Silva, Cazorla; FabregasInjured/Out: David de Gea
The South Americans will be playing the game of their life as a win will secure them a ticket to the knouckout stages.
A 3-1 morale boosting victory against Australia might be just what they needed to believe that they can get past the group phase, but it's easier said than done, especially, with a powerhouse like Spain getting in their way, and manager Jorge Sampaoli knows it.
"I think Spain's players are very experienced, very mature, so probably they'll play better than against the Netherlands," the Argentine told fifa.com.
"I think they will be difficult to beat. Don't forget they're one of the best teams in the world. I'm sure the game will be quite different because Spain are really strong and I'm pretty sure the Spain coach will have some sort of strategy for tomorrow (Wednesday)."
He is expected to employ a possession-based approach as he did against the Aussies, while hoping that FC Barcelona man Alexis Sanchez and company will be able to find their groove.
Projected Starters (4-3-1-2): Bravo; Mena, Isla, Medel, Jara; Aranguiz, Vidal, Diaz; Valdivia; Sanchez, VargasInjured/Out: N/A
Schedule and Free Live Streaming Information (Click on the links below):
Kick-off: 5 am, June 19, 2014 (Sydney Time)
Coverage via ESPN
Coverage via BBC
U.S. - [here]